Abstract
The major histocompatibility complex (MHC) genes are highly polymorphic and therefore have been useful in population genetics and disease association studies. We analyzed restriction fragment length polymorphism of HSP70-2 alleles in healthy unrelated Mestizo, Mazatecan and Nahua populations. Both Indian groups, Mazatecans and Nahuas, were in Hardy–Weinberg equilibrium, while Mestizos were in disequilibrium (χ2 = 0.399; P < 0.05). the mazatecan indians presented a high frequency of bb homozygosity (17.35%) compared to mestizos (5%) (p = 0.01). mexican ethnic groups present differences in distribution of bb genotype. the low frequency of bb genotype in mestizos may be the result of a negative selection process.
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Zúñiga, J., Vargas-Alarcón, G., Osnaya, N. et al. Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations. Genes Immun 1, 66–68 (1999). https://doi.org/10.1038/sj.gene.6363633
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DOI: https://doi.org/10.1038/sj.gene.6363633