During immune-cell development, potentially self-reactive T cells are eliminated. It emerges that recruitment of a co-receptor bound to the T-cell receptor by the enzyme Lck is the rate-limiting step in this negative selection.
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Gascoigne, N. Tolerance lies in the timing. Nature 515, 502–503 (2014). https://doi.org/10.1038/515502a
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DOI: https://doi.org/10.1038/515502a