It emerges that the sirtuin enzyme SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α. See Letter p.110
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Bheda, P., Wolberger, C. Sirtuin on a high-fat diet. Nature 496, 41–42 (2013). https://doi.org/10.1038/496041a
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DOI: https://doi.org/10.1038/496041a
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