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Infectious disease

Genomics decodes drug action

Drugs used to treat African sleeping sickness are outdated, and how they enter cells and exert biological effects is poorly understood. A genome-wide study using RNA interference provides valuable insight. See Letter p.232

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Figure 1: A genome-wide RNAi screen to identify antitrypanosome drug activity.

References

  1. Alsford, S. et al. Nature 482, 232–236 (2012).

    Article  ADS  CAS  Google Scholar 

  2. Meister, G. & Tuschl, T. Nature 431, 343–349 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Wirtz, E., Leal, S., Ochatt, C. & Cross, G. A. M. Mol. Biochem. Parasitol. 99, 89–101 (1999).

    Article  CAS  Google Scholar 

  4. Kolev, N. G., Tschudi, C. & Ullu, E. Eukaryot. Cell 10, 1156–1163 (2011).

    Article  CAS  Google Scholar 

  5. Berriman, M. et al. Science 309, 416–422 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Alsford, S. et al. Genome Res. 21, 915–924 (2011).

    Article  CAS  Google Scholar 

  7. Jacobs, R. T., Nare, B. & Phillips, M. A. Curr. Top. Med. Chem. 11, 1255–1274 (2011).

    Article  CAS  Google Scholar 

  8. Field, M. C., Lumb, J. H., Adung'a, V. O., Jones, N. G. & Engstler, M. Int. Rev. Cell Mol. Biol. 278, 1–67 (2009).

    Article  Google Scholar 

  9. Wilkinson, S. R., Taylor, M. C., Horn, D., Kelly, J. M. & Cheeseman, I. Proc. Natl Acad. Sci. USA 105, 5022–5027 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Frearson, J. A. et al. Nature 464, 728–732 (2010).

    Article  ADS  CAS  Google Scholar 

  11. Wyllie, S. et al. Mol. Microbiol. 74, 529–540 (2009).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Alan H. Fairlamb.

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Fairlamb, A. Genomics decodes drug action. Nature 482, 167–169 (2012). https://doi.org/10.1038/482167a

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