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Cancer

Let sleeping DNA lie

In hereditary breast and ovarian cancers caused by absence of the BRCA1 protein, genomic instability may ensue from the 'awakening' of repetitive DNA sequences in structurally condensed chromosomal regions. See Article p.179

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Figure 1: BRCA1 loss, satellite-DNA transcription and genomic instability.

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Correspondence to Ashok R. Venkitaraman.

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Venkitaraman, A. Let sleeping DNA lie. Nature 477, 169–170 (2011). https://doi.org/10.1038/477169a

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