In hereditary breast and ovarian cancers caused by absence of the BRCA1 protein, genomic instability may ensue from the 'awakening' of repetitive DNA sequences in structurally condensed chromosomal regions. See Article p.179
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zhu, Q. et al. Nature 477, 179–184 (2011).
Venkitaraman, A. R. Annu. Rev. Pathol. 4, 461–487 (2009).
Maison, C. & Almouzni, G. Nature Rev. Mol. Cell Biol. 5, 296–304 (2004).
Higashi, M., Inoue, S. & Ito, T. Exp. Cell Res. 316, 2707–2712 (2010).
Van Attikum, H. & Gasser, S. Trends Cell Biol. 19, 207–217 (2009).
Wang, H. et al. Nature 431, 873–878 (2004).
Zhang, F. et al. Curr. Biol. 19, 524–529 (2009).
Sy, S. M., Huen, M. S. & Chen, J. Proc. Natl Acad. Sci. USA 106, 7155–7160 (2009).
Reid, L. J. et al. Proc. Natl Acad. Sci. USA 105, 20876–20881 (2008).
Ting, D. T. et al. Science 331, 593–596 (2011).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Venkitaraman, A. Let sleeping DNA lie. Nature 477, 169–170 (2011). https://doi.org/10.1038/477169a
Published:
Issue Date:
DOI: https://doi.org/10.1038/477169a