Heart failure is characterized by weakened contractions of heart muscle. A drug that directly activates the key force-generating molecule in this muscle may be a valuable tool to strengthen the failing heart.
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The energy-saving effect of a new myosin activator, omecamtiv mecarbil, on LV mechanoenergetics in rat hearts with blood-perfused isovolumic contraction model
Naunyn-Schmiedeberg's Archives of Pharmacology Open Access 02 July 2019
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Bers, D., Harris, S. To the rescue of the failing heart. Nature 473, 37–39 (2011). https://doi.org/10.1038/473036a
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DOI: https://doi.org/10.1038/473036a
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