There are various ways in which apparently 'silent' DNA mutations — those that don't result in a change in the encoded protein — have untoward consequences. A striking example has emerged in a study of Crohn's disease.
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Hurst, L. The sound of silence. Nature 471, 582–583 (2011). https://doi.org/10.1038/471582a
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DOI: https://doi.org/10.1038/471582a
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