The protein OTUB1 inhibits DNA repair without using its enzymatic activity. Instead, it sequesters a protein that is required for the assembly of certain forms of ubiquitin chain, which function as key signals during repair.
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Rose, A., Schlieker, C. Blocking ubiquitin transfer. Nature 466, 929–930 (2010). https://doi.org/10.1038/466929a
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DOI: https://doi.org/10.1038/466929a
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