Time-resolved electron microscopy can capture structural changes in active macromolecular complexes, but detailed imaging is essential. The dynamics of one step in protein synthesis has been deduced from two million images.
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Ehrenberg, M. Translocation in slow motion. Nature 466, 325–326 (2010). https://doi.org/10.1038/466325a
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DOI: https://doi.org/10.1038/466325a