Polyketide synthase enzymes make compounds from molecules that synthetic chemists can't easily control. The basis of the enzymes' ability to use such unstable precursors has been laid bare.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Wilkinson, B. & Micklefield, J. Nature Chem. Biol. 3, 379–386 (2007).
Crawford, J. M. et al. Nature 461, 1139–1143 (2009).
Crawford, J. M. et al. Science 320, 243–246 (2008).
Leibundgut, M., Maier, T., Jenni, S. & Ban, N. Curr. Opin. Struct. Biol. 18, 714–725 (2008).
Harris, T. M. & Hay, J. V. J. Am. Chem. Soc. 99, 1631–1637 (1977).
Dillon, S. C. & Bateman, A. BMC Bioinformatics 5, 109 (2004).
Ames, B. D. et al. Proc. Natl Acad. Sci. USA 105, 5349–5354 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sherman, D. Enzyme's black box cracked open. Nature 461, 1068–1069 (2009). https://doi.org/10.1038/4611068a
Published:
Issue Date:
DOI: https://doi.org/10.1038/4611068a
