Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Malaria

The gatekeeper revealed

A molecular machine used by the malaria parasite to export its protein armoury into the host cell has at last been identified, providing researchers with a potentially invaluable therapeutic target.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Exporting malaria proteins across the vacuole.

References

  1. Scherf, A., Lopez-Rubio, J. J. & Riviere, L. Annu. Rev. Microbiol. 62, 445–470 (2008).

    Article  CAS  Google Scholar 

  2. Baird, J. K. N. Engl. J. Med. 352, 1565–1577 (2005).

    Article  CAS  Google Scholar 

  3. de Koning-Ward, T. F. et al. Nature 459, 945–949 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Crabb, B. S. et al. Cell 89, 287–296 (1997).

    Article  CAS  Google Scholar 

  5. Marti, M. et al. Science 306, 1930–1933 (2004).

    Article  ADS  CAS  Google Scholar 

  6. Hiller, N. L. et al. Science 306, 1934–1937 (2004).

    Article  ADS  CAS  Google Scholar 

  7. Bhattacharjee, S. et al. Blood 111, 2418–2426 (2008).

    Article  CAS  Google Scholar 

  8. Bhattacharjee, S. et al. PLoS Pathog. 2, e50 (2006).

    Article  Google Scholar 

  9. Grouffaud, S. et al. Microbiology 154, 3743–3751 (2008).

    Article  CAS  Google Scholar 

  10. Birch, P. R. et al. Curr. Opin. Plant Biol. 11, 373–379 (2008).

    Article  CAS  Google Scholar 

  11. Dou, D. et al. Plant Cell 20, 1930–1947 (2008).

    Article  CAS  Google Scholar 

  12. Combe, A. et al. Cell Host Microbe 5, 386–396 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reiff, S., Striepen, B. The gatekeeper revealed. Nature 459, 918–919 (2009). https://doi.org/10.1038/459918a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/459918a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing