Honeybees have helped scientists to sniff out a trigger of long-term memory formation. Calcium has been linked to this type of memory for more than a decade, but only recently have researchers directly manipulated it in the honeybee (Apis mellifera) to show that it can activate the formation of such memories.
Jean-Christophe Sandoz and his colleagues at the University of Toulouse in France tested honeybees' memories by first training them to extend their probosces for a sugary reward when presented with a specific odour. They then exposed the bees to the same odour three days later to see whether the bees remembered it. Injecting the bees with a chemical that decreased calcium availability impaired the insects' ability to remember. Conversely, injecting chemicals that increased calcium levels improved their long-term memory.
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Neurobiology: Sweet memories. Nature 459, 1036 (2009). https://doi.org/10.1038/4591036c
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DOI: https://doi.org/10.1038/4591036c