Sir

The Medical Research Council (MRC) recognizes the concerns of some sections of the UK biomedical community, as highlighted by Stephen Moss in his Correspondence 'Translational research: don't neglect basic science' (Nature 454, 274; 2008). The council has been clear that sustained investment in basic research — in laboratory-based as well as clinical and population settings — is an essential foundation for translational research.

The 30% increase in MRC funding over the current spending-review period includes a specific allocation for translational research. However, it also features increased funds for more basic studies. The only significant change for basic researchers is that it will be much easier for them to contribute to translational research and to work related to public health if they wish to do so.

The MRC has always recognized that giving talented investigators scope to pursue their ideas is one of the best ways to advance medical science. It will shortly be announcing the reintroduction of five-year-programme grants to improve support for longer-term research and risk-taking.

The council will continue to support a vibrant and well-resourced science base, acknowledging that investigator-led research, championed within the MRC and throughout the research community, is fundamental to what the MRC does.