Results can be thrust from bench to bedside, but there is also much to be learned by pushing the other way. Heidi Ledford tells tales of clinical trials that have prompted a change in tack.
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References
Mishra, R. A drug that works — for some. The Boston Globe (24 November 2003).
Metro, G. et al. Rev. Recent Clin. Trials 1, 1–13 (2006).
Lynch, T. J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Paez, J. G. et al. Science 304, 1497–1500 (2004).
Pao, W. et al. Proc. Natl Acad. Sci. USA 101, 13306–13311 (2004).
Engelman, J. A. et al. Science 316, 1039–1043 (2007).
Li, Z. et al. Science 296, 497 (2002).
Deichmann, A. et al. J. Clin. Invest. 117, 2225–2232 (2007).
Schwarzwaelder, K. et al. J. Clin. Invest. 117, 2241–2249 (2007).
Hacein-Bey-Abina, S. et al. Science 302, 415–419 (2003).
Thornhill, S. I. et al. Mol. Ther. 16, 590–598 (2008).
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Ledford, H. Translational Research: The full cycle. Nature 453, 843–845 (2008). https://doi.org/10.1038/453843a
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DOI: https://doi.org/10.1038/453843a
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