Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Paper
  • Published:

Evaluating dose regimens of apomorphine, an open-label study

International Journal of Impotence Research volume 15, pages S10–S12 (2003)Cite this article

Abstract

The aim of the study was to investigate the safety and efficacy of apomorphine SL (apo SL) 2 and 3 mg, using a dose-optimisation regime in 110 Asian men with erectile dysfunction (ED) during a 10-week open-label study. Based on daily diaries kept by each patient, 63% showed an improvement in their sexual life. Patient responses to the International Index for Erection Function 15 questionnaires showed that there was an improvement in erectile function from baseline score after treatment with apo SL (from 15.9 to 20.4), and intercourse satisfaction (from 7.7 to 9.9), as well as slight improvements in orgasmic function (from 6.8 to 7.5) and total satisfaction (from 41.9 to 50.8). There was no marked improvement seen in sexual desire. In conclusion, apo SL is safe and efficacious in the treatment of ED in this patient population, irrespective of underlying diseases and concomitant medications.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Thai Erectile Dysfunction Epidemiologic Study Group (TEDES). An epidemiological study of erectile dysfunction in Thailand (Part 1: prevalence). J Med Assoc Thai 2000; 83: 872–879.

  2. Thai Erectile Dysfunction Epidemiological Study Group. Kongkanand A . Prevalence of erectile dysfunction in Thailand. Int J Androl 2000; 23(Suppl 2): 77–80.

    Google Scholar 

  3. Von Keitz AT et al. A European multicentre study to evaluate the tolerability of apomorphine sublingual administered in a forced dose-escalation regimen in patients with erectile dysfunction. BJU Int 2002; 89: 409–415.

    Article  CAS  Google Scholar 

  4. Dula E, et al. Efficacy and safety of fixed-dose and dose-optimization regimens of sublingual apomorphine versus placebo in men with erectile dysfunction. The Apomorphine Study Group. Urology 2000; 56: 130–135.

    Article  CAS  Google Scholar 

  5. Rosen RC et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822–830.

    Article  CAS  Google Scholar 

  6. Dula E, Bukofzer S, Perdok R, George M . Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction. Eur Urol 2001; 39: 558–564.

    Article  CAS  Google Scholar 

  7. Mulhall JP, Bukofzer S, Edmonds AL, George M . An open-label, uncontrolled dose-optimization study of sublingual apomorphine in erectile dysfunction. Clin Ther 2001; 23: 1260–1271.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Urology, Department of Surgery, Chulalongkorn University Hospital, Bangkok, Thailand

    A Kongkanand, J Opanuraks & K Tantiwongse

  2. Phramongkutklao Hospital, Rajadevi, Bangkok, Thailand

    N Choeypunt

  3. Department of Surgery, Siriraj Hospital, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    A Tantiwong & T Amornvejsukit

Authors
  1. A Kongkanand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Opanuraks
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K Tantiwongse
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N Choeypunt
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Tantiwong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Amornvejsukit
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Kongkanand.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kongkanand, A., Opanuraks, J., Tantiwongse, K. et al. Evaluating dose regimens of apomorphine, an open-label study. Int J Impot Res 15 (Suppl 2), S10–S12 (2003). https://doi.org/10.1038/sj.ijir.3900992

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijir.3900992

Keywords

This article is cited by

Search

Advanced search

Quick links