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Antimicrobial activity of antibiotic-soaked, Resist™-coated Bioflex®

International Journal of Impotence Research volume 15, pages 18–21 (2003)Cite this article

Abstract

This study investigates whether a hydrophilic coating (Resist™), designed to inhibit bacterial adherence, applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of antibiotic-soaked Bioflex® (penile prosthetic substrate material) discs with and without Resist™ was examined by measuring the zone of inhibition following in vivo exposure in four groups of rabbits: 1, 2, 3 and 5 days' duration of disc implantation. Coated and uncoated discs were soaked in an aqueous solution of gentamicin and bacitracin. The implanted antibiotic-soaked discs were extracted, and the zone of inhibition against four microorganisms in vitro demonstrated that the Resist™ coating was especially effective against Staphylococcus epidermidis, and statistically significant improvements were observed for the coated over the uncoated substrate up to 3 days following implantation. This effect, and the anti-adherence properties of Resist™, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection.

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Acknowledgements

Supported in part by an unrestricted educational grant from Mentor Corporation, Santa Barbara, CA.

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  1. Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA

    W J G Hellstrom, J S Hyun, L Human, J A Sanabria, T J Bivalacqua & S Leungwattanakij

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  1. W J G Hellstrom
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  2. J S Hyun
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  3. L Human
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  4. J A Sanabria
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Correspondence to W J G Hellstrom.

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Hellstrom, W., Hyun, J., Human, L. et al. Antimicrobial activity of antibiotic-soaked, Resist™-coated Bioflex®. Int J Impot Res 15, 18–21 (2003). https://doi.org/10.1038/sj.ijir.3900941

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