A new process, antigenization of antibodies, consisting of the expression of oligopeptides in the hypervariable loops of an antibody molecule is described. The potential applications of antigenized antibodies are discussed.
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References
Atassi, M. Z. Molec. cell. Biochem. 32, 21–43 (1980).
Lerner, R. A. Scient. Am. 248, 66–74 (1983).
Geysen, H. M. Immunol. Today 6, 364–369 (1985).
Spangler, B. D. J. Immunol. 146, 1591–1595 (1991).
Newmark, P. Nature 305, 9 (1983).
Kunkel, T. A., Roberts, J. D. & Zakour, R. A. Meth. Enzym. 154, 367–382 (1987).
Newton, S. M., Jacob, C. O. & Stocker, B. A. Science 244, 70–72 (1989).
Kuwajima, G. et al. Bio/Technology 6, 1080–1083 (1988).
Jennings, P. A., Bills, M. M., Irving, D. O. & Mattick, J. S. Protein Eng. 2, 365–369 (1989).
Rutgers, T., et al. Bio/Technology 6, 1065–1070 (1988).
Reidhaarlson, J. F. & Sauer, R. T. Science 241, 53–57 (1988).
Cwirla, S. E., Peters, E. A., Barrett, R. W. & Dower, W. J. Proc. natn. Acad. Sci. U.S.A. 87, 6378–6382 (1990).
Devlin, J. J., Panganiban, L. C. & Devlin, P. E. Science 249, 404–406 (1990).
Scott, J. K. & Smith, G. P. Science 249, 386–390 (1990).
Zanetti, M., Billetta, R. & Sollazzo, M. in Anti-Idiotypic Vaccines (ed. Cazenave, P. A.) 123–134 (Springer, New York, 1991).
Alzari, P. M., Lacombe, M. -B. & Poljak, R. J. A. Rev. Immunol. 6, 555–580 (1988).
Kabat, E. A., Wu, E. T., Reidmiller, M., Perry, H. M. & Gottesman, K. S. Proteins of Immunologicat Interest (U.S. Department of Health and Human Services, Bethesda, 1987).
Chothia, C., Novotny, J., Bruccoleri, R. & Karplus, M. J. molec. Biol. 186. 651–663 (1985).
Novotny, J. & Franek, F. Nature 258, 641–643 (1975).
Verhoeyen, M., Milstein, C. & Winter, G. Science 239, 1534–1536 (1988).
Jones, T. P., Dear, P. H., Foote, J., Neuberger, M. & Winter, G. Nature 321, 522–525 (1986).
Riechmann, L., Clark, M., Waldmann, H. & Winter, G. Nature 332, 323–327 (1988).
Tempest, P. R., et al. Bio/Technology 9, 266–271 (1991).
Co, M. S., Deschamps, M., Whitley, R. J. & Queen, C. Proc. natn. Acad. Sci. U.S.A. 88, 2869–2873 (1991).
Sollazzo, M., Billetta, R. & Zanetti, M. Protein Eng. 4, 215–220 (1990).
Billetta, R., Hollingdale, R. M. & Zanetti, M. Proc. natn. Acad. Sci. U.S.A. 88, 4713–4717 (1991).
Ollier, P. R. S., Somme, G., Theze, J. & Fougereau, M. EMBO J. 4, 3681–3688 (1985).
Bruck, C., et al. Proc. natn. Acad. Sci. U.S.A. 83. 6578–6582 (1986).
Van, C. V., Naeve, C. W. & Metzger, D. W. J. exp. Med. 167, 1841–1848 (1988).
Hoffman, S., Nussenzweig, V., Sadoff, J. C. & Nussenzweig, R. S. Science 252. 520–521 (1991).
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Zanetti, M. Antigenized antibodies. Nature 355, 476–477 (1992). https://doi.org/10.1038/355476a0
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DOI: https://doi.org/10.1038/355476a0
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