Abstract
RHINOVIRUSES belong to the picornavirus family and cause about 50% of common colds1. Most rhinoviruses and some cox-sackie viruses share a common receptor on human cells. The glycoprotein intercellular adhesion molecule-1 (ICAM-1) has recently been identified as the cellular receptor for the subgroup of rhinoviruses known as the major groups2–4. ICAM-1 is a member of the immunoglobulin supergene family and is a ligand for lymphocyte function-associated antigen-1 (LFA-1)5–7; these ICAM-1/LFA-1 interactions are critical to many cell adhesion processes involved in the immunological response8–11. Because anti-ICAM-1 antibodies can block binding of major-group rhinoviruses to cells, we considered that antagonism of virus-receptor interaction might be a way of preventing rhinovirus infection. We have constructed and purified a soluble form of the ICAM-1 molecule, which is normally membrane-bound, and demonstrated that it is a potent and specific inhibitor of rhinovirus infection.
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References
1. Sperber, S. J. & Hayden, F. G. Antimicrob. Agents Chemother. 32, 409–419 (1988). 2. Greve, J. M. et al. Cell 56, 839–847 (1989). 3. Staunton, D. E. et al. Celi 56, 849–853 (1989). 4. Tomassini, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 86, 4907–4911 (1989). 5. Marlin, S. D. & Springer, T. A. Cell 51, 813–819 (1987). 6. Rothlein, R., Dustin, M. L., Marlin, S. D. & Springer, T. A. J. Immun. 137, 1270–1274 (1986). 7. Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L. & Springer, T. A. Cell 52, 925–933 (1988). 8. Dustin, M. L., Staunton, D. E. & Springer, T. A. Immun. Today 9, 213–215 (1988). 9. Kishimoto, T. K. et al. Adv. Immun. 46, 149–182 (1989). 10. Wawryk, S. O. et al. Immunol. Rev. 108, 1035–106 (1989). 11. Springer, ¤. "., Dustin, M. L., Kishimoto, T. K. & Marlin, S. D. A. Rev. Immun. 5, 223–252 (1987). 12. Colonno, R. J., Tomassini, J. E. & Callahan, P. L. Positive–strand RNA Viruses (eds Brinton, M. A. & Rueckert, R. R.) 92–102 (Liss, New York, 1987). 13. Rossman, M. G. J. biol. Chem. 264, 14587–14590 (1989). 14. Kunkel, T. A. Proc. natn. Acad. Sci. U.S.A. 82, 488–492 (1985). 15. Peterson, A. & Seed, B. Cell 54, 65–72 (1988). 16. Mulligan, R. C. & Berg, P. Proc. natn. Acad. Sci. U.S.A. 78, 2072–2076 (1981). 17. Mitchell, P. J., Urlaub, G. & Chasin, L. Molec. cell. Biol. 6, 425–440 (1986). 18. Graham, F. L. & van der Eb, A. J. Virology 52, 456–467 (1973). 19. Rothlein, R. et al. J. Immun. 141, 1665–1669 (1988). 20. Abraham, G. & Colonno, R. J. J. Virol. 51, 340–345 (1984).
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Marlin, S., Staunton, D., Springer, T. et al. A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection. Nature 344, 70–72 (1990). https://doi.org/10.1038/344070a0
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DOI: https://doi.org/10.1038/344070a0
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