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Muscle-specific gene expression controlled by a regulatory element lacking a MyoDl-binding site

Nature volume 341, pages 716–720 (1989)Cite this article

A Correction to this article was published on 24 May 1990

Abstract

Muscle-specific expression of the gene encoding the delta subunit of the acetylcholine receptor is controlled by a 54-base-pair region that does not contain a binding site for MyoDl, a protein involved in activation of the myogenic program. A MyoDl-binding site is present in the proximal promoter region of the gene encoding the δ-subunit, but is neither sufficient nor necessary for muscle-specific expression in transfected muscle cells.

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Authors and Affiliations

  1. Biology Department, 16-820 Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    T. J. Baldwin & S. J. Burden

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  1. T. J. Baldwin
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  2. S. J. Burden
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Baldwin, T., Burden, S. Muscle-specific gene expression controlled by a regulatory element lacking a MyoDl-binding site. Nature 341, 716–720 (1989). https://doi.org/10.1038/341716a0

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