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Transcription activation by the adenovirus E1a protein

Nature volume 338, pages 39–44 (1989)Cite this article

Abstract

The adenovirus Ela protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that Ela has the two functions characteristic of a typical cellular activator: one direct Ela to the promoter, perhaps by interacting with a DMA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts, 02138, USA

    James W. Lillie & Michael R. Green

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  1. James W. Lillie
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  2. Michael R. Green
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Lillie, J., Green, M. Transcription activation by the adenovirus E1a protein. Nature 338, 39–44 (1989). https://doi.org/10.1038/338039a0

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