Abstract
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H–Y) antigen in the context of class I H–2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CDS molecules, including nonmature CD4+CD8+ thymocytes, and is not caused by anti-idiotype cells.
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Kisielow, P., Blüthmann, H., Staerz, U. et al. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 333, 742–746 (1988). https://doi.org/10.1038/333742a0
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DOI: https://doi.org/10.1038/333742a0
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