Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts

Nature volume 331, pages 410–415 (1988)Cite this article

Abstract

Regulation of transcription during development has been analysed in vitro using extracts derived from Drosophila embryos. Transcription of mutant templates reveals cis- control regions of the alcohol dehydrogenase promoter responsible for temporal regulation. The activity of a transacting protein correlates with the profile of alcohol dehydrogenase expression during embryogenesis

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Scott, M. P. & O'Farrell, P. H. A. Rev. Cell. Biol. 2, 49–80 (1986).

    Article  CAS  Google Scholar 

  2. Gehring, W. J. Science 236, 1245–1252 (1987).

    Article  ADS  CAS  Google Scholar 

  3. Maniatis, T., Goodbourn, S. & Fischer, J. A. Science 236, 1237–1245 (1987).

    Article  ADS  CAS  Google Scholar 

  4. Ursprung, H., Sofer, W. H. & Burroughs, N. Wilhelm Roux Arch. dev. Biol. 164, 201–208 (1970).

    Article  Google Scholar 

  5. Savakis, C., Ashburner, M. & Willis, J. H. Devl Biol 114, 194–207 (1986).

    Article  CAS  Google Scholar 

  6. Benyajati, C., Spoerel, N., Haymerle, H. & Ashburner, M. Cell 33, 125–133 (1983).

    Article  CAS  Google Scholar 

  7. Fisher, J. A. & Maniatis, T. EMBO J. 5, 1275–1289 (1986).

    Article  Google Scholar 

  8. Posakony, J. W. Fischer, J. A. & Maniatis, T. Cold Spring Harbor Symp. quant. Biol. 50, 515–520 (1986).

    Article  Google Scholar 

  9. Heberlein, U., England, B. & Tjian, R. Cell 41, 965–977 (1985).

    Article  CAS  Google Scholar 

  10. Echalier, G. & Ohanessian, A. C. R. Acad. Sci. (Paris), Ser. B. 268, 1771–1773 (1969).

    CAS  Google Scholar 

  11. Soeller, W. C., Poole, S. J. & Kornberg, T. Genes Dev. (in the press).

  12. Bond, B. J. & Davidson, N. Molec. cell. Biol. 6, 2080–2099 (1986).

    Article  CAS  Google Scholar 

  13. Zalokar, M. Devl Biol. 49, 425–437 (1976).

    Article  CAS  Google Scholar 

  14. Anderson, K. V. & Lengyel, J. A. Devl Biol. 70, 217–231 (1979).

    Article  CAS  Google Scholar 

  15. McKnight, S. L. & Miller, O. L. Jr Cell 8, 305–319 (1976).

    Article  CAS  Google Scholar 

  16. Edgar, B. A. & Schubinger, G. Cell 44, 871–877 (1986).

    Article  CAS  Google Scholar 

  17. Galas, D. & Schmitz, A. Nucleic Acids Res. 5, 3157–3170 (1978).

    Article  CAS  Google Scholar 

  18. Kadonaga, J. T. & Tjian, R. Proc. natn. Acad. Sci. U.S.A. 83, 5889–5893 (1986).

    Article  ADS  CAS  Google Scholar 

  19. Briggs, M. R. Kadonaga, J. T. Bell, S. P. & Tjian, R. Science 234, 47–52 (1986).

    Article  ADS  CAS  Google Scholar 

  20. Dynan, W. S. & Tjian, R. Nature 316, 774–778 (1985).

    Article  ADS  CAS  Google Scholar 

  21. McKnight, S. & Tjian, R. Cell 46, 795–805 (1986).

    Article  CAS  Google Scholar 

  22. Serfling, E., Jasin, M. & Schaffner, W. Trends Genet. 1, 224–230 (1985).

    Article  CAS  Google Scholar 

  23. Sen, R. & Baltimore, D. Cell 47, 921–928 (1986).

    Article  CAS  Google Scholar 

  24. Pyrwes, R. & Roeder, R. G. Cell 47, 777–784 (1986).

    Article  Google Scholar 

  25. Hayes, T. E., Kitchen, A. M. & Cochran, B. H. Proc. natn. Acad. Sci. U.S.A. 84, 1272–1276 (1987).

    Article  ADS  CAS  Google Scholar 

  26. Kingston, R. E., Schuetz, T. J. & Larin, Z. Molec. cell. Biol. 7, 1530–1534 (1987).

    Article  CAS  Google Scholar 

  27. Zimarino, V. & Wu, C. Nature 327, 727–730 (1987).

    Article  ADS  CAS  Google Scholar 

  28. Laughon, A., Boulet, A. M. Bermingham, J. R. Jr, Laymon, R. A. & Scott, M. P. Molec. cell. Biol. 6, 4676–4689 (1986).

    Article  CAS  Google Scholar 

  29. Schneuwly, S., Kuriowa, A., Baumgartner, P. & Gehring, W. J. EMBO J. 5, 733–739 (1986).

    Article  CAS  Google Scholar 

  30. Marsch, J. L. & Wright, T. R. F. Devl Biol. 80, 379–387 (1980).

    Article  Google Scholar 

  31. Hirsch, J. & Davidson, N. Mol. cell Biol. 1, 475–485 (1981).

    Article  Google Scholar 

  32. Kraminsky, G. P. et al. Proc. natn. Acad. Sci. U.S.A. 77, 4175–4179 (1980).

    Article  ADS  CAS  Google Scholar 

  33. O'Hare, K., Lewis, R. & Rubin, G. M. Proc. natn. Acad. Sci. U.S.A. 80, 6917–6921 (1983).

    Article  ADS  CAS  Google Scholar 

  34. McKnight, S. L. & Kingsbury, R. Science 217, 316–324 (1982).

    Article  ADS  CAS  Google Scholar 

  35. Fyrberg, E. A., Kindle, K. L., Davidson, N. & Sodja, A. Cell 19, 365–378 (1980).

    Article  CAS  Google Scholar 

  36. Goldberg, D. A. Proc. natn. Acad. Sci. U.S.A. 77, 5794–5798 (1980).

    Article  ADS  CAS  Google Scholar 

  37. Maxam, A. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley, California, 94720, USA

    Ulrike Heberlein & Robert Tjian

Authors
  1. Ulrike Heberlein
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert Tjian
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heberlein, U., Tjian, R. Temporal pattern of alcohol dehydrogenase gene transcription reproduced by Drosophila stage-specific embryonic extracts. Nature 331, 410–415 (1988). https://doi.org/10.1038/331410a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/331410a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing