Abstract
Transmission of the bovine papillomavirus-1 (BPV-1) genome through the mouse germ line results in the heritable formation of fibropapillomas of the skin, a tissue-specific phenotype analogous to that observed in natural BPV-1 infection of cattle. Oncogenesis is slow, with tumours first arising at 8–9 months of age, usually in areas prone to wounding. Extrachromosomal BPV-1 DNA is detected in all tumours, whereas normal tissues show only integrated DNA.
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Lacey, M., Alpert, S. & Hanahan, D. Bovine papillomavirus genome elicits skin tumours in transgenic mice. Nature 322, 609–612 (1986). https://doi.org/10.1038/322609a0
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DOI: https://doi.org/10.1038/322609a0
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