The prospect of live vaccines consisting of genetically modified vaccinia virus expressing foreign genes is exciting, but important issues concerning safety and efficacy need to be resolved.
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Brown, F., Schild, G. & Ada, G. Recombinant vaccinia viruses as vaccines. Nature 319, 549–550 (1986). https://doi.org/10.1038/319549a0
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DOI: https://doi.org/10.1038/319549a0
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