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Automated continuous flow peptide synthesis

An Erratum to this article was published on 20 February 1986

As peptide-based drugs and reagents become a reality, a new method of peptide synthesis is beginning to come into its own.

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References

  1. Audibert, F. et al. Proc. natn. Acad. Sci. U.S.A. 79, 5042 (1982).

    Article  ADS  CAS  Google Scholar 

  2. Merrifield, R.B. Fedn Proc. 21, 41 (1962): J. Am. chem. Soc. 85, 2149 (1963).

    Google Scholar 

  3. Sano, S. & Kawanishi, S. Am. chem. Soc. 97, 3480 (1975).

    Article  CAS  Google Scholar 

  4. Feinberg, R.S. & Merrifield, R. B. J. Am. chem. Soc. 97, 3485 (1975).

    Article  CAS  Google Scholar 

  5. Brandt, W.F., Henschen, A. & Van Holt, C. in Methods in Protein Sequence Analysis (ed. Elzinga, M.) 101–109 (Humana Clifton, New Jersey, 1982).

    Book  Google Scholar 

  6. Ondetti, M.A., Deer, A., Sheenan, J.T., Pluscic, J. & Kocy, O. Biochemistry 7, 4069 (1968).

    Article  CAS  Google Scholar 

  7. Wade, J.D., Fitzgerald, S.P., McDonald, M.R., McDougall, J.G. & Treger, G.W. Biopolymers (in press).

  8. Atherton, E., Gait, M.J., Sheppard, R.C. & Williams, B.J. Bioorgan. Chem. 8, 351– 370 (1979).

    Article  CAS  Google Scholar 

  9. Sheppard, R.C. Chem. Brit. 19, 402–414 (1983).

    CAS  Google Scholar 

  10. Atherton, E., Clive, D.L.J. & Sheppard, R.C. J.C.S. Perkin 529–537 (1981).

  11. Atherton, E., Logan, C.J., & Sheppard, R.C. J.C.S. Perkin I 529–537 (1981).

  12. Sheppard, R.C. & Williams, B.J. Int. J. Peptide Protein Res. 20, 451–454 (1982).

    Article  CAS  Google Scholar 

  13. Atherton, E., Brown, E. & Sheppard, R.C. JCS Chem. Commun., 1151–1152 (1981).

  14. Auffret, A.D. & Meade, L.G. Proc. Synth. Peptides Biol. Med., Hämeenlinna, Finland 6–8 June 1985 (in press).

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Andrews, R. Automated continuous flow peptide synthesis. Nature 319, 429–430 (1986). https://doi.org/10.1038/319429a0

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