Abstract
The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation5 and the equivalent Y-located locus, MIC2Y, was one of the first genes shown to reside on a mammalian Y chromosome2. By using a bacterial expression system we have previously cloned a complementary DNA sequence corresponding to a MIC2 gene and have used this probe to show that the MIC2X and MIC2Y loci are closely related, if not identical6. Here we report the use of the cloned probe to confirm the localization of the MIC2X locus to the region Xpter–Xp22.32 (ref. 7) and demonstrate, for the first time, that the MIC2Y locus is located on the short arm of the Y chromosome in the distal region Ypter–Yp11.2. The MIC2 sequences and the sequences described in the accompanying papers by Cooke et al.8 and Simmler et al.9 are the first which have been shown to be shared by the sex chromosomes in the pairing region.
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Goodfellow, P. N., Banting, G., Levy, R., Povey, S. & McMichael, A. Somat. Cell Genet. 6, 777–787 (1980).
Goodfellow, P. N. et al. Nature 302, 346–349 (1983).
Goodfellow, P. N. Differentiation 23(s), 25–39 (1983).
Goodfellow, P. N., Darling, S. & Wolfe, J. J. med. Genet. (in the press).
Goodfellow, P. N., Pym, B., Mohandas, T. & Shapiro, L. J. Am. J. hum. Genet. 36, 777–782 (1984).
Darling, S., Banting, G., Pym, B., Wolfe, J. & Goodfellow, P. N. Proc. nat. Acad. Sci. U.S.A. (in the press).
Curry, C. J. R. et al. New Engl. J. Med. 311, 1010–1015 (1984).
Cooke, H. J., Brown, W. R. A. & Rappold, G. A. Nature 317, 687–692 (1985).
Simmler, M. C. et al. Nature 317, 692–697 (1985).
Jacobs, P. A. & Strong, J. A. Nature 183, 302–303 (1959).
Ford, C. E., Jones, K. W., Polani, P. E., de Almeida, J. C. & Briggs, J. H. Lancet 1, 711–713 (1959).
Miller, O. J., Goodfellow, P. N. & Drayna, D. Cytogenet. Cell Genet. 37, 176–204 (1984).
Burgoyne, P. S. Hum. Genet. 61, 85–90 (1982).
Pearson, P. L. & Bobrow, M. Nature 226, 959–961 (1970).
Chen, A. & Falek, A. Nature 232, 555–556 (1971).
Chandley, A. C., Goetz, P., Hargreave, T. B., Joseph, A. M. & Speed, R. M. Cytogenet. Cell Genet. 38, 241–247 (1984).
Koller, P. C. & Darlington, C. D. J. Genet. 29, 159–173 (1934).
Singh, L. & Jones, K. Cell 28, 205–216 (1982).
Evans, E. O., Burtenshaw, M. & Cattanach, B. M. Nature 300, 443–445 (1982).
Keitges, E., Rivest, M., Siniscalco, M. & Gartler, S. M. Nature 315, 226–227 (1985).
Erickson, R. P. & Goodfellow, P. N. Nature 311, 106–107 (1984).
Page, D. C., Harper, M. E., Love, J. & Botstein, D. Nature 311, 119–123 (1984).
Cooke, H. J., Brown, W. R. A. & Rappold, G. A. Nature 311, 259–261 (1984).
Koenig, M., Camerino, G., Heilig, R. & Mandel, J.-L. Nucleic Acids Res. 12, 4097–4109 (1984).
Marcus, M., Trantravali, R., Dev, J. G., Miller, D. A. & Miller, O. J. Nature 262, 65–67 (1976).
Hope, R. M., Goodfellow, P. N., Solomon, E. & Bodmer, W. F. Cytogenet. Cell Genet. 33, 204–212 (1982).
Bishop, C. E. et al. Nature 303, 831–832 (1983).
Minowada, J., Ohnuma, T. & Moore, G. E. J. natn. Cancer Inst. 49, 891–895 (1972).
Klebe, R. J., Chen, T. & Ruddle, F. H. J. Cell Biol. 45, 74–82 (1970).
Nabholz, M., Miggiano, V. & Bodmer, W. F. Nature 223, 358–363 (1969).
Kohler, G. & Milstein, C. Nature 256, 495–497 (1975).
Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning (Cold Spring Harbor Laboratory, New York, 1982).
Zabel, B. U., Naylor, S. L., Sakaguchi, A. Y., Bell, G. J. & Shows, T. B. Proc. nat. Acad. Sci. U.S.A. 80, 6932–6936 (1983).
Boyd, Y. et al. Ann. hum. Genet. 48, 145–152 (1984).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Buckle, V., Mondello, C., Darling, S. et al. Homologous expressed genes in the human sex chromosome pairing region. Nature 317, 739–741 (1985). https://doi.org/10.1038/317739a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/317739a0
This article is cited by
-
PBDX is the XG blood group gene
Nature Genetics (1994)
-
Multiple DNA-protein interactions at the CpG island of the human pseudoautosomal geneMIC2
Somatic Cell and Molecular Genetics (1993)
-
Unequal crossing over and heterochromatin exchange in the X-Y bivalents of the deer mouse,Peromyscus beatae
Chromosoma (1990)
-
Genetic analysis of tumorigenesis: XXXII. Localization of constitutionally amplifiedKRAS sequences to Chinese hamster chromosomes X and Y by in situ hybridization
Somatic Cell and Molecular Genetics (1988)
-
Synaptic behaviour and recombination nodules in the human XY pair
Genetica (1988)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
