Abstract
Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV)1–3are invariably neoplasms of cells with mature T-lymphocyte phenotype4,5. Epstein–Barr virus-transformed B-lymphocyte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies6,7, but no non-lymphoid tissues seem to be involved. Here, to investigate the basis for this tissue specificity, we introduced type II HTLV (HTLV-II) into a variety of human cells by infection and also by transfection of recombinant genomes. We found no HTLV-II expression in non-lymphoid tissues although expression and correct initiation of transcription was observed in B and T lymphocytes. Our results using recombinant genomes indicate that the restriction of expression is at least partly due to cis-acting functions of the long terminal repeats which lie at each end of the HTLV genome.
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References
Poiesz, B. J. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7415–7419 (1980).
Hinuma, Y. et al. Proc. natn. Acad. Sci. U.S.A. 78, 6476–6480 (1981).
Kalyanaraman, V. S. et al. Science 218, 571–573 (1982).
Gallo, R. C. et al. Cancer Res. 43, 3892–3899 (1983).
Saxon, A., Stevens, R. H. & Golde, D. W. Ann. intern. Med. 88, 323–326 (1978).
Yamamoto, N., Matsumoto, T., Koyanagi, Y., Tanaka, Y. & Hinuma, Y. Nature 299, 367–369 (1982).
Chen, I. S. Y., Quan, S. G. & Golde, D. W. Proc. natn. Acad. Sci. U.S.A. 80, 7006–7009 (1983).
Glaser, R. & Nonoyama, M. J. Virol. 14, 174–176 (1974).
Glaser, R. & Rapp, F. J. Virol. 10, 288–296 (1972).
Southern, E. M. & Berg, P. J. molec. appl. Genet. 1, 327–341 (1982).
Bacchetti, S. & Graham, F. L. Proc. natn. Acad. Sci. U.S.A. 74, 590–594 (1977).
Wigler, M. et al. Cell 16, 777–785 (1979).
Chen, I. S. Y., McLaughlin, J., Gasson, J.C., Clark, S.C. & Golde, D.W. Nature 305, 502–505 (1983).
Temin, H. M. Cell 27, 1–3 (1981).
Temin, H. M. Cell 28, 3–5 (1982).
Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. Cell 33, 717–728 (1983).
Chandler, V. L., Maler, B. A. & Yamamoto, K. R. Cell 33, 489–499 (1983).
Southern, E.M. J. molec. Biol. 98, 503–517 (1975).
Rhim, J. S., Cho, H. Y. & Huebner, R. J. Int. J. Cancer 15, 23–29 (1975).
Shimotohno, K., Golde, D. W., Miwa, M., Sugimura, T. & Chen, I. S. Y. Proc. natn. Acad. Sci. U S. A. 81, 1079–1083 (1984).
Seiki, M., Hattori, S., Hirayama, Y. & Yoshida, M. Proc. natn. Acad. Sci. U.S.A. 80, 3618–3622 (1983).
Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).
Queen, G. & Baltimore, D. Cell 33, 741–748 (1983).
Thomas, P. S. Proc. natn. Acad. Sci. U.S.A. 77, 5201–5205 (1980).
Berk, A. J. & Sharp, P. A. Cell 12, 721–732 (1977).
Schaffner, W. Proc. natn. Acad. Sci. U.S.A. 77, 2163–2167 (1980).
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Chen, I., McLaughlin, J. & Golde, D. Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity. Nature 309, 276–279 (1984). https://doi.org/10.1038/309276a0
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DOI: https://doi.org/10.1038/309276a0
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