Abstract
The maternally transmitted antigen (Mta) is expressed on the cells of most strains of mice1,2. It is a medial histocompatibility antigen3, that is, it is recognized by unrestricted cytotoxic T lymphocytes as are major H antigens, but unlike these it is a weak transplantation antigen and does not itself restrict the T-cell recognition of minor H antigens. All other medial H antigens are encoded by genes closely linked to the major histocompatibility complex3, H–2 in the mouse. By contrast, Mta appeared to follow extrachromosomal, maternal inheritance. Several substrains of NZB, NZO and non-inbred European NMRI mice are Mta-negative. Females of these strains bear only Mta− offspring, while females of the inbred Mta+ strains bear only Mta+ offspring. Repeated backcrossing from Mta+ females to NZB or NMRI males has shown that, given the right cytoplasmic genes, the chromosomal genes of these Mta− strains permit expression of Mta2. As the Mta type of a mouse cannot be influenced by embryo transfer or foster nursing2,4, we concluded that it was determined by a cytoplasmic factor (Mtf), transmitted through the egg. We now show that a gene, Hmt, closely linked to the H–2 complex, is also required for expression of Mta.
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References
Fischer Lindahl, K., Bocchieri, M. & Riblet, R. J. exp. Med. 152, 1583–1595 (1980).
Fischer Lindahl, K. & Hausmann, B. Genetics 103, 483–494 (1983).
Fischer Lindahl, K. & Langhorne, J. Scand. J. Immun. 14, 643–654 (1981).
Fischer Lindahl, K. & Bürki, K. Proc. natn. Acad. Sci. U.S.A. 79, 5362–5366 (1982).
Ferris, S. D., Ritte, U., Fischer Lindahl, K., Prager, E. M. & Wilson, A. C. Nucleic Acids Res. 11, 2917–2926 (1983).
Chan, T. & Fischer Lindahl, K. Ann. Rep. Basel Inst. Immun. 11, 90 (1982).
Winoto, A., Steinmetz, M. & Hood, L. Proc. natn. Acad. Sci. U.S.A. 80, 3425–3429 (1983).
Klein, J. The Biology of the Mouse Histocompatibility-2 Complex (Springer, New York, 1975).
Chapman, V. M., Nichols, E. A. & Ruddle, F. H. Biochem. Genet. 11, 347–358 (1974).
Chapman, V. M., Kratzer, P. G. & Quarantillo, B. A. Genetics 103, 785–795 (1983).
Shiroishi, T., Sagai, T. & Moriwaki, K. Nature 300, 370–372 (1982).
Klein, D., Tewarson, S., Figueroa, F. & Klein, J. Immunogenetics 16, 319–328 (1982).
Marshall, J. T. Jr, Bull. Am. Mus. natl. Hist. 158, 175–220 (1977).
Tada, N., Kimura, S., Hatzfeld, A. & Hämmerling, U. Immunogenetics 11, 441–449 (1980).
Kimura, S., Tada, N., Liu, Y. & Hämmerling, U. Immunogenetics 14, 445–447 (1981).
Tomonari, K., Tada, N., Kimura, S., Hämmerling, U. & Weksler, M. E. Immunogenetics 15, 605–608 (1982).
Chorney, M., Shen, F.-W., Michaelson, J. & Boyse, E. A. Immunogenetics 16, 91–93 (1982).
Ozato, K., Mayer, N. & Sachs, D. H. J. Immun. 124, 533–540 (1980).
Ozato, K., Mayer, N. & Sachs, D. H. Transplantation 34, 113–120 (1982).
Köhler, G., Fischer Lindahl, K. & Heusser, C. in The Immune System Vol. 2 (eds Steinberg, C. M. & Lefkovits, I.) 202–208 (Karger, Basel, 1981).
Lemke, H., Hämmerling, G. J. & Hämmerling, U. Immun. Rev. 47, 175–206 (1976).
Fischer Lindahl, K. & Lemke, H. Eur. J. Immun. 9, 526–536 (1979).
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Lindahl, K., Hausmann, B. & Chapman, V. A new H–2-linked class I gene whose expression depends on a maternally inherited factor. Nature 306, 383–385 (1983). https://doi.org/10.1038/306383a0
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DOI: https://doi.org/10.1038/306383a0
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