Abstract
Considerable evidence for shared antigenic determinants between nervous elements and lymphocytes has accumulated1–3. It has also been suggested that this cross-recognition may be involved in the pathogenesis of human neurological diseases such as myasthenia gravis1,4 and multiple sclerosis2. We report here evidence that a marker for natural killer (NK) cells, anti-Leu-7 (HNK-1)5, specifically binds to components of human and rodent central nervous tissue as well as peripheral nervous tissue, especially to myelin sheaths. In contrast, another NK-cell marker (VEP13)6 did not react with nervous tissue. Since NK-cell function is impaired in a population of multiple sclerosis patients7–9, the observed cross-reactivity indicates that autosensitization against myelin may simultaneously cause a defect of NK-cell function. Furthermore, the shared antigenic determinant may help to identify a hitherto undefined nervous tissue antigen and simultaneously increase the knowledge about the nature of NK-cell antigens.
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Schuller-Petrovic, S., Gebhart, W., Lassmann, H. et al. A shared antigenic determinant between natural killer cells and nervous tissue. Nature 306, 179–181 (1983). https://doi.org/10.1038/306179a0
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DOI: https://doi.org/10.1038/306179a0
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