Abstract
Deletion of specific nucleotides at either end of the long terminal repeat of the avian retrovirus, spleen necrosis virus, results in replication-competent but integration-defective virus. This result supports two conclusions: (1) the 5-base pair terminal inverted repeats and three to seven adjacent nucleotides are required for integration; (2) integration of retrovirus DNA is not required for retrovirus gene expression.
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Panganiban, A., Temin, H. The terminal nucleotides of retrovirus DNA are required for integration but not virus production. Nature 306, 155–160 (1983). https://doi.org/10.1038/306155a0
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DOI: https://doi.org/10.1038/306155a0
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