Abstract
We have previously suggested that two lymphokine activities–macrophage activating factor (MAF) and γ interferon (IFN-γ)–are mediated by the same molecule1,2. Striking similarities were noted in their cellular biosynthesis, rate of inactivation with acid treatment and heating, and elution profiles on Sepha-cryl S-200. In addition, highly specific polyclonal antibodies to murine IFN-γ neutralized MAF and IFN-γ to a similar degree. However, definitive studies require a pure product and we now report that murine IFN-γ that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity. But it is not yet known whether IFN-γ is responsible for all the MAF activity in media conditioned by T cells as the possibility for MAF heterogeneity remains.
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References
Schultz, R. M. & Chirigos, M. A. Cancer Res. 38, 1003–1007 (1978).
Kleinschmidt, W. J. & Schultz, R. M. J. Interferon Res. 2, 291–299 (1982).
Ruco, L. P. & Meltzer, M. S. J. Immun. 121, 2035–2042 (1981).
Schultz, R. M. & Chirigos, M. A. Cell Immun. 48, 52–58 (1979).
Schultz, R. M. J. Interferon Res. 2, 459–466 (1982).
Kelso, A., Glasebrook, A. L., Kanagawa, O. & Brunner, T. J. Immun. 129, 550–556 (1982).
Roberts, W. K. & Vasil, A. J. Interferon Res. 2, 519–532 (1982).
Mannel, D. N. & Falk, W. Cell Immun. 70, 389 (1982).
Mantovani, A., Dean, J. H., Jerrells, T. R. & Herberman, R. B. Int. J. Cancer 25, 691–699 (1980).
Boraschi, D. & Tagliabue, A. Eur. J. Immun. 11, 110–114 (1981).
Benjamin, W. R., Steeg, P. S. & Farrar, J. J. Proc. natn. Acad. Sci. U.S.A. 79, 5379–5383 (1982).
Kniep, E. M., Domzig, W., Lohmann-Matthes, M. & Kickhofen, B. J. Immun. 127, 417–422 (1982).
Meltzer, M. S., Farrar, J. J., Benjamin, W. F. & Nacy, C. A. Cell. Immun. 70, 401 (1982).
Ratliff, T. L., Thomasson, D. L., McCool, R. E. & Catalona, W. J. Cell. Immun. 68, 311–321 (1982).
Schreiber, R. D., Altman, A. & Katz, D. H. J. exp. Med. 156, 677–689 (1982).
Yamamoto, Y., Tomida, M. & Hozumi, M. Gann 73, 557–564 (1982).
Gray, P. W. & Goeddel, D. V. Proc. natn. Acad. Sci. U.S.A. (in the press).
Vogel, S. N., Weedon, L. L., Moore, R. N. & Rosenstreich, D. L. J. Immun. 128, 380–387 (1982).
Steeg, P. S., Moore, R. N., Johnson, H. M. & Oppenheim, J. J. J. Immun. (in the press).
Steeg, P. S., Moore, R. N., Johnson, H. M. & Oppenheim, J. J. J. exp. Med. 156, 1780–1783 (1982).
Meltzer, M. S. J. Immun. 127, 179–183 (1981).
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Schultz, R., Kleinschmidt, W. Functional identity between murine γ Interferon and macrophage activating factor. Nature 305, 239–240 (1983). https://doi.org/10.1038/305239a0
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DOI: https://doi.org/10.1038/305239a0
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