Abstract
Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products1–4. Cells expressing accessory cell function include those of the monocyte/macrophage lineage5,6 and dendritic cells7,8. More recently, B cells9 and a number of tumour cell lines of macrophage or B-cell origin10–17 were shown to act as accessory cells in certain assays. We showed previously that normal peritoneal exudate macrophages (PEC) induced both T-cell proliferation as well as T-cell help, whereas various Ia+ tumour lines of macrophage or B-cell origin, although stimulating antigen-specific T-cell proliferation, did not significantly activate T-cell help18,19. We report here that during the initial T-cell activation in vitro accessory cells (PEC or Ia+ tumour cells) select particular T cells to express previously determined functions. Moreover, some tumour cell lines induce suppressor T cells which inhibit helper activity.
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Ramila, G., Erb, P. Accessory cell-dependent selection of specific T-cell functions. Nature 304, 442–445 (1983). https://doi.org/10.1038/304442a0
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DOI: https://doi.org/10.1038/304442a0
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