Abstract
The H-2 I region in the mouse and the HLA-D region in humans contain a set of polymorphic genes which encode Ia antigens and control the immune response. Cloned genes for the different polypeptide chains of one of the human Ia antigens, HLA-DR, have been used for the co-transformation of mouse L cells. Expression of HLA-DR antigens at the surface of transfected mouse cells has been documented with monoclonal antibodies.
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Rabourdin-Combe, C., Mach, B. Expression of HLA-DR antigens at the surface of mouse L cells co-transfected with cloned human genes. Nature 303, 670–674 (1983). https://doi.org/10.1038/303670a0
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DOI: https://doi.org/10.1038/303670a0
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