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The effects of α chain mutations cis and trans to the β6 mutation on the polymerization of sickle cell haemoglobin

Nature volume 299, pages 231–234 (1982)Cite this article

Abstract

The solubility of polymers formed by haemoglobins with one βs chain and one mutant α chain, either cis or trans to each other, has revealed three distinct regions on the surface of the tetramer which participate in intermodular bonding within the haemoglobin S fibre.

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Authors and Affiliations

  1. Department of Biochemistry, Columbia University, College of Physicians and Surgeons, New York, New York, 10032, USA

    Ruth E. Benesch, Suzanna Kwong & Reinhold Benesch

Authors
  1. Ruth E. Benesch
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  2. Suzanna Kwong
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  3. Reinhold Benesch
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Benesch, R., Kwong, S. & Benesch, R. The effects of α chain mutations cis and trans to the β6 mutation on the polymerization of sickle cell haemoglobin. Nature 299, 231–234 (1982). https://doi.org/10.1038/299231a0

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