Abstract
It is well established that strong proliferative responses in mixed lymphocyte culture (MLC)1 are controlled by gene products of the HLA-D locus, but stimulation between HLA-D identical individuals does occur and may partly be due to differences at the HLA-A, or HLA-B loci. However, many unrelated individuals who type identically for HLA-A, -B, -C, and -D/DR determinants have also been shown to be mutually stimulatory. The development of the primed lymphocyte test (PLT) provided a powerful tool in the identification of these non-HLA loci2–9. Using this test, we show here that significant HLA-restricted proliferative responses occurred in association with M or N blood group antigens.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dupont, B., Hansen, J. & Yunis, E. Adv. Immun. 23, 107–202 (1976).
Sheehy, M. J., Sondel, P. M., Bach, M. L., Wank, R. & Bach, F. H. Science 188, 1308–1310 (1975).
Fradelizi, D. & Dausset, J. Eur. J. Immun. 5, 295–301 (1975).
Singal, D. P. Transplantn Proc. 10, 771–774 (1978).
Singal, D. P. Transplantn Proc. 11, 1813–1815 (1979).
Sasaportes, M., Nunez-Roldan, A. & Fradelizi, D. Immunogenetics 6, 55–68 (1979).
Wank, R., Schendel, D. J., Hansen, J. A. & Dupont, B. Immunogenetics 6, 107–115 (1979).
Singal, D. P., Blajchman, M. A., Naipaul, N. & Josephs, S. Hum. Immun. 2, 201–211 (1981).
Singal, D. P. & Naipaul, N. Transplantn Proc. 9, 1755–1757 (1977).
Terasaki, P. I., Bernoco, D., Park, M. S., Ozturk, G. & Iwaki, Y. Am. J. clin. Path. 69, 103–120 (1978).
Segrest, J. P., Kahane, I., Jackson, R. L. & Marchesi, V. T. Archs Biochem. Biophys. 155, 167–183 (1973).
Tomita, M. & Marchesi, V. T. Proc. natn. Acad. Sci. U.S.A. 72, 2964–2968 (1975).
Dahr. W., Unlenbruck, G., Janssen, E. & Schmalisch, R. Hum. Genet. 35, 335–343 (1977).
Anstee, D. J. Semin. Hemat. 18, 13–31 (1981).
Race, R. R. & Sanger, R. Blood Groups in Man, 92–138 (Blackwell, Oxford, 1975).
Sparkes, R. S. et al. Tissue Antigens 15, 212–215 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Blajchman, M., Heddle, N., Naipul, N. et al. HLA-restricted lymphoproliferative responses to MN blood group determinants. Nature 299, 67–69 (1982). https://doi.org/10.1038/299067a0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/299067a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.