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Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue

Nature volume 296, pages 158–160 (1982)Cite this article

Abstract

Coeliac sprue is a disease in humans that is characterized by small intestinal mucosal injury and malabsorption. Ingestion of dietary gluten by susceptible individuals results in damage to the small intestine. The gliadin fractions of wheat gluten and similar proteins in rye and barley are known to activate the disease process1. The major histocompatibility complex (MHC) alleles HLA-B8, Dw3 and DRw3 occur at a high frequency in coeliac sprue2–5, suggesting that immunoregulatory mechanisms may be important in the pathogenesis of the disease. We recently reported that murine antibody responses to A-gliadin, a well characterized protein known to activate coeliac sprue1,6–9, are regulated by genes that map to H–2, the murine MHC10. However, it appeared that an additional genetic locus also might be important in regulating the immune response to gliadin proteins. We show here that two separate genetic regions determine the murine antibody response to A-gliadin: H–2 on chromosome 17 and the immunoglobulin heavy chain (CH) allotype locus (Igh) on chromosome 12. Possible ways in which these two loci could determine the response against A-gliadin are discussed.

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References

  1. Kasarda, D. D. in Food, Nutrition, and Evolution (eds Walcher, D. & Kretchmer, M.) 201–216 (Masson, New York, 1981).

    Google Scholar 

  2. Falchuk, Z. M., Rogentine, G. N. & Strober, W. J. clin. Invest. 51, 1602–1605 (1972).

    Article  CAS  Google Scholar 

  3. Keuning, J. J. et al. Lancet i, 506–507 (1976).

    Article  Google Scholar 

  4. Ek, J., Albrechtsen, D., Solheim, B. G. & Thorsby, E. Scand. J. Gastroenterol. 13, 229–233 (1978).

    Article  CAS  Google Scholar 

  5. Polanco, I. et al. in The Genetics of Coeliac Disease (ed. McConnell, R. B.) 211–230 (MTP Press, Lancaster, 1981).

    Book  Google Scholar 

  6. Platt, S. G. & Kasarda, D. D. Biochim. biophys. Acta 243, 407–415 (1971).

    Article  CAS  Google Scholar 

  7. Kasarda, D. D., Bernardin, J. E. & Nimmo, C. C. in Advances in Cereal Science and Technology Vol. 1 (ed. Pomeranz, Y.) 158–236 (American Association of Cereal Chemists, St Paul, Minnesota, 1976).

    Google Scholar 

  8. Kasarda, D. D. Ann. Technol. Agric. 29, 151–173 (1980).

    CAS  Google Scholar 

  9. Autran, J.-C., Lew, E. J.-L., Nimmo, C. C. & Kasarda, D. D. Nature 282, 527–529 (1979).

    Article  ADS  CAS  Google Scholar 

  10. Trefts, P. E. & Kagnoff, M. F. J. Immun. 126, 2249–2252 (1981).

    CAS  PubMed  Google Scholar 

  11. Lieberman, R., Potter, M., Mushinski, E. B., Humphrey, W. Jr & Rudikoff, S. J. exp. Med. 139, 983–1001 (1974).

    Article  CAS  Google Scholar 

  12. Riblet, R. et al. Eur. J. Immun. 5, 775–777 (1975).

    Article  CAS  Google Scholar 

  13. Lieberman, R. Springer Semin. Immunopath. 1, 7–30 (1978).

    Article  Google Scholar 

  14. Bottomly, K. & Mosier, D. E. J. exp. Med. 150, 1399–1409 (1979).

    Article  CAS  Google Scholar 

  15. Woodland, R. & Cantor, H. Eur. J. Immun. 8, 600–606 (1978).

    Article  CAS  Google Scholar 

  16. Hetzelberger, D. & Eichmann, K. Eur. J. Immun. 8, 846–852 (1978).

    Article  CAS  Google Scholar 

  17. Adorini, L., Harvey, M. & Sercarz, E. E. Eur. J. Immun. 9, 906–909 (1979).

    Article  CAS  Google Scholar 

  18. Trefts, P. E., Rivier, D. A. & Kagnoff, M. F. Nature 292, 163–165 (1981).

    Article  ADS  CAS  Google Scholar 

  19. Herzenberg, L. A. et al. J. exp. Med. 144, 330–344 (1976).

    Article  CAS  Google Scholar 

  20. Jacobson, E. B. J. exp. Med. 148, 607–612 (1978).

    Article  CAS  Google Scholar 

  21. Slack, J., Der-Balian, G. P., Nahm, M. & Davie, J. M. J. exp. Med. 151, 853–862 (1980).

    Article  CAS  Google Scholar 

  22. Rolink, T., Eichmann, K. & Simon, M. M. Immunogenetics 7, 321–336 (1978).

    Article  CAS  Google Scholar 

  23. Riblet, R. & Congleton, C. Immunogenetics 5, 511 (1977).

    Google Scholar 

  24. Owen, F. L., Finnegan, A., Gates, E. R. & Gottlieb, P. D. Eur. J. Immun. 9, 948–955 (1979).

    Article  CAS  Google Scholar 

  25. Owen, F. L., Riblet, R. & Taylor, B. A. J. exp. Med. 153, 801–810 (1981).

    Article  CAS  Google Scholar 

  26. Pisetsky, D. S., Riordan, S. E. & Sachs, D. H. J. Immun. 122, 842–846 (1979).

    CAS  PubMed  Google Scholar 

  27. Claflin, J. L., Wolfe, J. & Ruppert, V. J. J. Immun. 123, 2088–2090 (1979).

    CAS  PubMed  Google Scholar 

  28. Weigert, M. & Riblet, R. Springer Semin. Immunopath. 1, 133–169 (1978).

    Article  Google Scholar 

  29. van Rood, J. J., van Hooff, J. P. & Keuning, J. J. Transplantn Rev. 22, 75–105 (1975).

    Google Scholar 

  30. Pena, A. S. et al. Gastroenterology 75, 230–235 (1978).

    CAS  PubMed  Google Scholar 

Download references

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  1. Department of Medicine, University of California at San Diego, La Jolla, California, 92093, USA

    Martin F. Kagnoff

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Kagnoff, M. Two genetic loci control the murine immune response to A-gliadin, a wheat protein that activates coeliac sprue. Nature 296, 158–160 (1982). https://doi.org/10.1038/296158a0

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