Abstract
Cellular interactions between alloreactive cytolytic T lymphocytes (CTLs) and helper T cells have been suggested by the results of experiments in which lymphocyte subpopulations were defined by antisera against cell-surface markers1 or by differential response to antigenic stimulation2,3. The development of T-cell cloning technology has allowed the isolation of alloreactive cloned helper and cytolytic cells, and the demonstration of collaboration between them in the generation of cytotoxicity4,5. Whereas some types of alloantigen-specific cloned T cells, including helper cells, proliferate in tissue culture in response to antigenic stimulation4–6, CTLs isolated thus far do not and require for proliferation the addition of exogenous T-cell growth factors (TCGFs) or helper cells which produce TCGF in response to antigenic stimulation4,5,7–10. We demonstrate here, at the clonal level, the existence of another type of CTL which proliferates in response to allogeneic stimulating cells without the overt addition of TCGF; it produces helper-like factor and thus can be characterized as a helper cell-independent CTL.
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Widmer, M., Bach, F. Antigen-driven helper cell-independent cloned cytolytic T lymphocytes. Nature 294, 750–752 (1981). https://doi.org/10.1038/294750a0
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DOI: https://doi.org/10.1038/294750a0
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