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The role of gene dosage and genetic transpositions in carcinogenesis

Nature volume 294, pages 313–318 (1981)Cite this article

Abstract

Analysis of chromosome translocations associated with B-cell derived tumours and studies of chromosome-15 trisomy in murine leukaemia support the theory, emerging from recent work on tumour viruses, that cancer can be associated with DNA rearrangements which result in the increased expression of normal cellular genes.

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Authors and Affiliations

  1. Department of Tumor Biology, Karolinska Institutet, S-104 01, Stockholm, Sweden

    George Klein

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Klein, G. The role of gene dosage and genetic transpositions in carcinogenesis. Nature 294, 313–318 (1981). https://doi.org/10.1038/294313a0

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