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Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae

Nature volume 294, pages 88–90 (1981)Cite this article

Abstract

Carbohydrate and protein antigens have been shown to elicit the bulk of their antibodies in mutually exclusive IgG subclasses in humans, mice, rats and horses1–4. In the mouse, anti-protein antibodies are primarily of the IgG1 subclass, and anti-carbohydrate antibodies are primarily of the IgG3 subclass1,2. We have now demonstrated that mouse IgG3 antibodies to the phosphocholine (PC) determinant of pneumococcal C-carbohydrate5,6 and to type 3 pneumococcal polysaccharide are highly protective against experimental type 3 pneumococcal infection. This is the first demonstration that antibodies of the IgG3 subclass can protect against bacterial infection.

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Authors and Affiliations

  1. Cellular Immunobiology Unit of the Tumor Institute, Department of Microbiology, and Comprehensive Cancer Center, University of Alabama in Birmingham, Birmingham, Alabama, 35294, USA

    David E. Briles & Colynn Forman

  2. Department of Microbiology and Immunology, University of Michigan, Medical School, Ann Arbor, Michigan, 48109, USA

    J. Latham Claflin

  3. Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, 20205, USA

    Kenneth Schroer

Authors
  1. David E. Briles
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  2. J. Latham Claflin
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  3. Kenneth Schroer
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  4. Colynn Forman
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Briles, D., Latham Claflin, J., Schroer, K. et al. Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae. Nature 294, 88–90 (1981). https://doi.org/10.1038/294088a0

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