Abstract
African trypanosomes evade their mammalian host's immune system by the sequential expression of alternative surface glycoproteins. Comparison of the cDNA sequences of five antigenically distinct surface proteins and the C-terminal amino acid sequences of four additional ones demonstrates that these nine glycoproteins can be classified into two subsets based on C-terminal amino acid homologies that extend 75–105 amino acids into the protein.
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References
de Raadt, P. & Seed, J. R. in Parasitic Protozoa Vol. 1 (ed. Kreier, J. P.) 175–237 (Academic, New York, 1977).
Wld Hlth Org. Documn TDR/WP 76.6 & 76.12 (WHO, Geneva, 1976).
Bridgen, P. J., Cross, G. A. M. & Bridgen, J. Nature 263, 613–614 (1976).
Vickerman, K. Nature 273, 613–617 (1978).
Capbern, A., Giroud, C., Baltz, T. & Mattern, P. Expl Parasit. 42, 6–13 (1977).
Cross, G. A. M. Proc. R. Soc. B202, 55–72 (1978).
Cross, G. A. M. Parasitology 71, 398–417 (1975).
Barbet, A. F. & McGuire, T. C. Proc. natn. Acad. Sci. U.S.A. 75, 1989–1993 (1978).
Johnson, J. G. & Cross, G. A. M. Biochem. J. 178, 689–697 (1979).
Johnson, J. G. & Cross, G. A. M. J. Protozool. 24, 587–591 (1977).
Cross, G. A. M. & Johnson, J. G. in Biochemistry of Parasites and Host-Parasite Relationships (ed. Van der Bossche, H.) 413–430 (North-Holland, Amsterdam, 1976).
Doyle, J. J. in Immunity to Blood Parasites in Animals and Man (eds Miller, L., Pino, J. & McKelvey, J.) 27–63 (Plenum, New York, 1977).
Barbet, A. F. & McGuire, T. C. Proc. natn. Acad. Sci. U.S.A. 75, 1989–1993 (1978).
Williams, R. O., Young, J. R. & Majiwa, P. A. O. Nature 282, 847–849 (1979).
Williams, R. O., Young, J. R., Majiwa, P. A. O., Doyle, J. J. & Shapiro, S. Z. Cold Spring Harb. Symp. quant. Biol. 45, 945–949 (1980).
Donelson, J. E., Young, J. R., Majiwa, P. A. O. & Williams, R. O. J. molec. Biol. (submitted).
Marcu, K. B. & Williams, R. O. in Genetic Engineering Vol. 3 (eds Setlow, J. K. & Hollaender, A.) 129–156 (Plenum, New York, 1981).
Boothroyd, J. C., Cross, G. A. M., Hoeijmakers, J. H. J. & Borst, P. Nature 288, 624–626 (1980).
Cunningham, M. P. & Vickerman, K. Trans. R. Soc. trop. Med. Hyg. 56, 48–59 (1962).
Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 852–862 (1975).
Hoeijmakers, J. H. J., Borst, P., Van Den Burg, J., Weissman, C. & Cross, G. A. M. Gene 8, 391–417 (1980).
Min Jou, W. et al. Cell 19, 683–696 (1980).
Efstratiadis, A. et al. Cell 21, 653–668 (1980).
Verhoeyen, M. et al. Nature 236, 771–776 (1980).
Air, G. & Hall, R. ICN–UCLA Symp. molec. cell. Biol. 17 (in the press).
Holder, A. A. & Cross, G. A. M. Molec. biochem. Parasit. 2, 135–150 (1981).
Honjo, T. & Kataoka, T. Proc. natn. Acad. Sci. U.S.A. 75, 2140–2144 (1978).
Borst, P. et al. Cold Spring Harb. Symp. quant. Biol. 45, 935–943 (1980).
Pays, E., Van Meirvenne, N., Le Ray, D. & Steinert, M. Proc. natn. Acad. Sci. U.S.A. 78, 2673–2677 (1981).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).
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Rice-Ficht, A., Chen, K. & Donelson, J. Sequence homologies near the C-termini of the variable surface glycoproteins of Trypanosoma brucei. Nature 294, 53–57 (1981). https://doi.org/10.1038/294053a0
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DOI: https://doi.org/10.1038/294053a0
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