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Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal

Nature volume 293, pages 540–542 (1981)Cite this article

Abstract

Cloned genomic retroviral DNA is expressed in mouse zygotes after microinjection. The resulting virus integrated into the mouse genome at a single chromosomal site and was expressed in a tissue-specific manner. Our findings suggest that the chromosomal position of a viral genome influences its activation during development.

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, 2000, Hamburg, 20, FRG

    Klaus Harbers, Detlev Jähner & Rudolf Jaenisch

Authors
  1. Klaus Harbers
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  2. Detlev Jähner
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  3. Rudolf Jaenisch
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Harbers, K., Jähner, D. & Jaenisch, R. Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 293, 540–542 (1981). https://doi.org/10.1038/293540a0

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