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Adult tissues contain chemo-attractants for vascular endothelial cells

Nature volume 288, pages 483–484 (1980)Cite this article

Abstract

New blood vessel formation, or angiogenesis, occurs through the migration of endothelial cells in elongated sprouts. These sprouts are directed preferentially towards the inciting stimulus1–3. Several studies have demonstrated that certain chemical substances can stimulate angiogenesis4–7. In these cases, endothelial cell migration towards the chemical stimulus may be due to a preferential migration of cells from lower to higher concentrations of the mediator. Such concentration gradient-dependent cellular migration has been termed chemotaxis8. Using a modification of the Boyden chamber technique9 to measure chemotaxis in vitro, we have now found that extracts of various adult bovine tissues have potent chemotactic activity for vascular endothelial cells. Adult bovine serum lacks similar chemotactic activity.

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Authors and Affiliations

  1. Wilmer Ophthalmologic Institute, The Johns Hopkins University School of Medicine and The Johns Hopkins Hospital, Baltimore, Maryland, 21205

    Bert M. Glaser & Patricia A. D'Amore

  2. Laboratory of Development Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20205

    Heikki Seppa, Silja Seppa & Elliott Schiffmann

Authors
  1. Bert M. Glaser
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  2. Patricia A. D'Amore
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  3. Heikki Seppa
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  4. Silja Seppa
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  5. Elliott Schiffmann
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Glaser, B., D'Amore, P., Seppa, H. et al. Adult tissues contain chemo-attractants for vascular endothelial cells. Nature 288, 483–484 (1980). https://doi.org/10.1038/288483a0

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