Abstract
Immunoglobulins function as antigen receptors of B lymphocytes and as effector molecules for elimination of foreign antigens. Recently, other functions have been revealed: for example, idiotypes (antigenic sites of variable (V) domains) bound on the surface of plasmacytomas1,2 can act as tumour-specific transplantation antigens3. Moreover, optimal maturation of B lymphocytes of a given idiotype into antibody-secreting cells seems to require assistance from two different kinds of helper T cells (Th), one bearing receptors complementary or similar to that idiotype, and another that recognizes the antigen4–6. To learn more about recognition of V regions by Th, we have used V-domains of the immunoglobulin A (IgA) (λ 2) myeloma protein M315 produced by the BALB/c plasma-cytoma MOPC 315 (ref. 7) as carriers for anti-hapten responses. We report here that the Th response to the V-domain of the heavy chain (VH) and the light chain (VL) of M315 seems to be under H–2-linked immune response (IR) gene control.
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Jørgensen, T., Hannestad, K. H–2-linked genes control immune response to V-domains of myeloma protein 315. Nature 288, 396–397 (1980). https://doi.org/10.1038/288396a0
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DOI: https://doi.org/10.1038/288396a0
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