Abstract
Anti-inflammatory steroids reduce prostaglandin (PG) synthesis in intact cells and isolated organs1–9 by interfering indirectly with the phospholipase(s) which release the poly-unsaturated fatty acid precursors for both cyclooxygenase and lipoxygenase pathways. This action requires nucleic acid transcription and synthesis of new protein,10–12 and a soluble factor capable of inhibiting PG generation has been identified11,13. However, it is not known whether these steroids affect either the actions or content of the enzymes of the PG system after adminstration in vivo, nor is it known if they affect PG-metabolizing enzymes. We show here that treatment of rats with anti-inflammatory steroids causes rapid changes in tissue activities of enzymes which synthesize and inactivate PGs, with apparent levels reduced and increased respectively.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gryglewski, R. J., Panczenko, B., Korbut, R., Grodzinska, L. & Ocetkiewicz, A. Prostaglandins 10, 343–355 (1975).
Lewis, G. P. & Piper, P. J. Nature 254, 308–311 (1975).
Kantrowitz, F., Robinson, D. R., McGuire, M. B. & Levine, L. Nature 258, 737–739 (1975).
Tashjian, A. H., Voelkel, E. F., McDonough, J. & Levine, L. Nature 258, 739–741 (1975).
Floman, Y. & Zor, U. Prostaglandins 12, 403–413 (1976).
Nijkamp, F. P., Flower, R. J., Moncada, S. & Vane, J. R. Nature 263, 479–482 (1976).
Hong, S-C. L. & Levine, L. Proc. natn. Acad. Sci. U.S.A. 73, 1730–1734 (1976).
Blackwell, G. J., Flower, R. J., Nijkamp, F. P. & Vane, J. R. Br. J. Pharmac. 62, 79–89 (1978).
Tarn, S., Hong, S-C. L. & Levine, L. J. Pharmac. exp. Ther. 203, 162–168 (1977).
Danon, A. & Assouline, G. Nature 273, 552–554 (1978).
Flower, R. J. & Blackwell, G. J. Nature 278, 456–459 (1979).
di Rosa, M. & Persico, P. Br. J. Pharmac. 66, 161–163 (1979).
Carnuccio, R., di Rosa, M. & Persico, P. Br. J. Pharmac. 68, 14–16 (1980).
Hoult, J. R. S. & Moore, P. K. Br. J. Pharmac. 68, 719–730 (1980).
Hoult, J. R. S. & Moore, P. K. Clin. Sci. 59, 63–66 (1980).
Haynes, R. C. Jr & Lamer, J. in The Pharmacological Basis of Therapeutics 5th edn (eds Goodman, L. S. & Gilman, A.) 1472–1506 (Macmillan, New York, 1975).
Samuels, H. H. & Tomkins, G. M. J. molec. Biol. 52, 57–74 (1970).
Baxter, J. D. & Forsham, P. A. Am. J. Med. 53, 573–589 (1972).
Thompson, E. B. & Lippmann, M. E. Metabolism 23, 159–202 (1974).
Chan, J. A., Nagasawa, M., Takeguchi, C. & Sih, C. J. Biochemistry 14, 2987–2991 (1975).
Cottee, F., Flower, R. J., Moncada, S., Salmon, J. A. & Vane, J. R. Prostaglandins 14, 413–423 (1977).
Hansen, H. S. Prostaglandins 12, 647–679 (1976).
Moore, P. K. & Hoult, J. R. S. Nature 288, 271–273 (1980).
Ferreira, S. H. & Vane, J. R. A. Rev. Pharmac. 14, 57–73 (1974).
Bonta, I. L. & Parnham, M. J. Biochem. Pharmac. 27, 1611–1623 (1978).
Parrillo, J. E. & Fauci, A. S. A. Rev. Pharmac. Tox. 19, 179–201 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Moore, P., Hoult, J. Anti-inflammatory steroids reduce tissue PG synthetase activity and enhance PG breakdown. Nature 288, 269–270 (1980). https://doi.org/10.1038/288269a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/288269a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
