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Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma

Nature volume 287, pages 603–607 (1980)Cite this article

Abstract

Leader, variable (V) and joining (J) gene segments, and adjacent regions of two rearranged alleles of the same κ-chain producing mouse myeloma, comprising approximately 3,200 base pairs, have been sequenced. Sequence comparisons are reported. V–J joining in one of the alleles leads to a reading frame with a stop codon within the J-gene segment. Allelic exclusion is apparently realized in this tumour through the formation of such a non-functional allele.

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Author notes

  1. Werner Altenburger

    Present address: Institut für Molekularbiologie II der Universität Zürich, Hönggerberg, 8093, Zürich, Switzerland

  2. Michael Steinmetz

    Present address: Division of Biology, California Institute of Technology, Pasadena, California, 91125

Authors and Affiliations

  1. Institute für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München, FRG

    Werner Altenburger, Michael Steinmetz & Hans G. Zachau

Authors
  1. Werner Altenburger
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  2. Michael Steinmetz
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  3. Hans G. Zachau
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Altenburger, W., Steinmetz, M. & Zachau, H. Functional and non-functional joining in immunoglobulin light chain genes of a mouse myeloma. Nature 287, 603–607 (1980). https://doi.org/10.1038/287603a0

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