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A unifying model for the G1 period in prokaryotes and eukaryotes

Abstract

A model to explain the cell division cycle in both prokaryotes and eukaryotes is presented. No specific ‘G1 functions’ take place during the G1 period, which is merely part of a larger period for the preparation of DNA synthesis which began at the previous initiation of DNA synthesis. A G1 period exists merely because the doubling time of the cells is greater than the sum of the S and G2 periods.

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References

  1. Helmstetter, C. & Cooper, S. J. molec. Biol. 31, 507–518 (1968).

    Article  CAS  Google Scholar 

  2. Cooper, S. & Helmstetter, C. E. J. molec. Biol. 31, 519–540 (1968).

    Article  CAS  Google Scholar 

  3. Mendelson, M. L., Dohen, F. C. & Moore, H. A. J. natn. Acad. Cancer Inst. 25, 477–484 (1960).

    Google Scholar 

  4. Sisken, J. E. & Kinosita, R. J. biophys. biochem. Cyt. 9, 509–518 (1961).

    Article  CAS  Google Scholar 

  5. Young, R. W. Expl Cell Res. 26, 562–567 (1962).

    Article  CAS  Google Scholar 

  6. Defendi, V. & Manson, L. A. Nature 198, 359–361 (1963).

    Article  ADS  Google Scholar 

  7. Cameron, I. L. J. Cell Biol. 20, 185–188 (1964).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Cameron, I. L. & Greulich, R. C. J. Cell Biol. 18, 31–40 (1963).

    Article  CAS  Google Scholar 

  9. Tobey, R. A., Anderson, E. C. & Petersen, D. F. J. Cell Biol. 35, 53–59 (1967).

    Article  CAS  Google Scholar 

  10. Prescott, D. M. Reproduction of Eucaryotic Cells (Academic, New York, 1976).

    Google Scholar 

  11. Helmstetter, C. E. & Pierucci, O. J. molec. Biol. 102, 477–486 (1976).

    Article  CAS  Google Scholar 

  12. Robbins, E. & Scharff, M. D. J. Cell Biol. 34, 684–686 (1967).

    Article  CAS  Google Scholar 

  13. Liskay, R. M. J. cell. Physiol. 84, 49–56 (1974).

    Article  CAS  Google Scholar 

  14. Liskay, R. M. Expl Cell Res. 114, 69–77 (1978).

    Article  CAS  Google Scholar 

  15. Liskay, R. M. & Prescott, D. M. Proc. natn. Acad. Sci. U.S.A. 75, 2873–2877 (1978).

    Article  ADS  CAS  Google Scholar 

  16. Donachie, W. D., Jones, N. C. & Teather, R. in Microbial Differentiation (eds Ashworth, J. M. & Smith, J. E.) 9–44 (Cambridge University Press, 1973).

    Google Scholar 

  17. Mitchison, J. M. The Biology of the Cell Cycle (Cambridge University Press, 1971).

    Google Scholar 

  18. Pardee, A. B., Dubrow, R., Hamlin, J. L. & Kletzien, R. F. A. Rev. Biochem. 47, 715–750 (1978).

    Article  CAS  Google Scholar 

  19. Tobey, R. A., Gurley, L. R., Hildebrand, C. E., Ratliff, R. L. & Walters, R. A. in Control of Proliferation in Animal Cells (eds Clarkson, B. & Baserga, R.) 665–679 (Cold Spring Harbor Laboratory, New York, 1974).

    Google Scholar 

  20. Helmstetter, C. E., Cooper, S., Pierucci, O. & Revelas, E. Cold Spring Harb. Symp. quant. Biol. 33, 809–822 (1968).

    Article  CAS  Google Scholar 

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Cooper, S. A unifying model for the G1 period in prokaryotes and eukaryotes. Nature 280, 17–19 (1979). https://doi.org/10.1038/280017a0

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