Abstract
GLUCOCORTICOIDS decrease levels of circulating peripheral lymphocytes and immunoglobulins, inhibit mitogen- and antigen-induced blastogenesis of cultured lymphocytes and decrease bactericidal activity of granulocytes and other phagocytic cells1–4. Fc receptors on granulocytes are thought to play a vital part in adherence of antibody-coated particles to the surfaces of these cells, a step which initiates phagocytosis5. Factors which regulate the expression of the Fc receptor could therefore influence phagocytic capability, and it has been suggested that glucocorticoids might act in such a way6,7. We report here that glucocorticoids inhibit expression of the Fc receptor on the human promyelocytic cell line HL-60 (ref. 8). This inhibition is not accompanied by increased cell death, reduced proliferation or a general reduction in protein synthesis.
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CRABTREE, G., MUNCK, A. & SMITH, K. Glucocorticoids inhibit expression of Fc receptors on the human granulocytic cell line HL-60. Nature 279, 338–339 (1979). https://doi.org/10.1038/279338a0
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DOI: https://doi.org/10.1038/279338a0
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