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Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids

Nature volume 277, pages 534–538 (1979)Cite this article

Abstract

The human α- and β-globin genes have been activated in MEL × human fibroblast cell hybrids. However, even though the human γ- and β-globin genes are closely linked and were shown in these hybrid clones to be present in approximately equal numbers, no human γ-globin mRNA was produced. Thus, the human β- and γ-globin genes in these cells are differentially regulated apparently by a positive regulatory factor(s) specific for individual globin genes.

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Authors and Affiliations

  1. Laboratory of Molecular Hematology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20014

    Marcia C. Willing, Arthur W. Nienhuis & W. French Anderson

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  1. Marcia C. Willing
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  2. Arthur W. Nienhuis
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  3. W. French Anderson
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Willing, M., Nienhuis, A. & Anderson, W. Selective activation of human β - but not γ-globin gene in human fibroblast × mouse erythroleukaemia cell hybrids. Nature 277, 534–538 (1979). https://doi.org/10.1038/277534a0

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