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Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis

Nature volume 277, pages 28–32 (1979)Cite this article

Abstract

PC 1 Duarte, a common variant of a human brain-specific protein, is present in one-third of the control population and has a gene frequency of 0.17. There was a significantly increased frequency of mutant heterozygotes and homozygotes among individuals with depressive disease. This is consistent with a model in which Pc 1 Duarte is the major gene in depressive disease, acting in conjunction with an environmental threshold effect.

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Authors and Affiliations

  1. Department of Medical Genetics, City of Hope National Medical Center, Duarte, California, 91010

    David E. Comings

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  1. David E. Comings
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Comings, D. Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis. Nature 277, 28–32 (1979). https://doi.org/10.1038/277028a0

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