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AUG is the only recognisable signal sequence in the 5′ non-coding regions of eukaryotic mRNA

Nature volume 274, pages 84–87 (1978)Cite this article

Abstract

THE nucleotide sequence of the 5′ non-coding region of messenger RNAs is particularly interesting because it may contain the signals for processing and modification of mRNA, such as its cleavage from precursor and ‘capping’ (the addition of the 5′ terminal m7Gppp) and possible recognition and binding sites for ribosomes and initiation factors. We have reported the complete sequence of the 5′ non-coding region of rabbit globin mRNA—the first non-viral eukaryotic mRNA1, followed by similar studies on human and rabbit α and β-globin mRNAs2,3. Here we report the sequence of the 5′ non-coding regions of mouse α-globin, βmin-globin and βmaj-globin mRNA and make a detailed comparative study of this region.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK

    FRANCISCO E. BARALLE & GEORGE G. BROWNLEE

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  1. FRANCISCO E. BARALLE
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  2. GEORGE G. BROWNLEE
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BARALLE, F., BROWNLEE, G. AUG is the only recognisable signal sequence in the 5′ non-coding regions of eukaryotic mRNA. Nature 274, 84–87 (1978). https://doi.org/10.1038/274084a0

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